Nautant® 125mg + 80mg Capsules (Aprepitant) – Anti-Nausea Medicine (Rx)

Quick answer: Nautant 125mg (aprepitant) is a three-day capsule pack that helps stop chemotherapy from causing nausea and vomiting. It holds one 125mg capsule and two 80mg capsules, taken by mouth with other anti-sickness medicines. MedHub supplies it on prescription with delivery throughout Pakistan.

For patients and families

What is Nautant 125mg?

Nautant 125mg is a complete course of aprepitant for one chemotherapy cycle, made in Pakistan by Pharmasol. The pack contains a larger starting capsule and two follow-on capsules. Aprepitant blocks NK1 receptors in the brain, the switches that substance P uses to set off vomiting. Blocking them protects you on treatment day and through the two difficult days that follow.

What is it used for?

Cancer doctors prescribe this pack, together with a steroid and another anti-sickness medicine, for adults and young people aged 12 and over who are about to have:

• Chemotherapy with a high chance of sickness, for example regimens based on cisplatin
• Chemotherapy with a moderate chance of sickness

It covers both early sickness within the first 24 hours and delayed sickness over the next few days. Many patients also receive Cispatin 50mg (cisplatin) or Carbosol 450mg (carboplatin) during the same cycle.

How is it taken?

You swallow each capsule whole with water, with or without a meal. You start with the 125mg capsule on chemotherapy day, then use the two 80mg capsules on the following days, exactly as your doctor directs. Your doctor decides the dose and the other medicines that go with it.

Common side effects

• Feeling tired
• Hiccups that come and go
• Loss of appetite
• Constipation, diarrhoea or heartburn
• Headache

Seek urgent help for any sign of allergy, such as a swollen face, lips or tongue, difficulty breathing or a sudden rash. Also report it if you keep vomiting despite the capsules.

The pill, patch or other hormonal contraception may not work properly during treatment and for 28 days after. Use an extra barrier method, and mention warfarin or any other regular medicine to your doctor.

Storage

Keep the pack below 30°C in a dry place, sealed in its blister until each dose, and safely away from children.

How to order from MedHub

1. Send a photo of your prescription on WhatsApp.
2. Our pharmacist confirms the price and stock with you.
3. We deliver the pack in good time for your chemotherapy date.

Families in the UAE, UK and Saudi Arabia often order Nautant 125mg a few days ahead of a parent’s chemotherapy so nothing is missed. If the doctor asks for extra follow-on capsules, ask us about Nautant 80mg, or browse our oncology medicines.

For healthcare professionals

• Composition: aprepitant 125 mg hard capsule (1) and aprepitant 80 mg hard capsules (2)
• Drug class: NK1 receptor antagonist, antiemetic
• Indications: prevention of acute and delayed nausea and vomiting associated with highly emetogenic cisplatin-based cancer chemotherapy and moderately emetogenic cancer chemotherapy in adults and adolescents aged 12 years and older, as part of combination therapy
• Mechanism: high-affinity antagonism of substance P at brain NK1 receptors, complementing 5-HT3 antagonists and corticosteroids, with activity in both acute and delayed phases
• Label dose: 125 mg orally 1 hour before chemotherapy on day 1; 80 mg once daily in the morning on days 2 and 3; given with a corticosteroid and a 5-HT3 antagonist
• Monitoring / key precautions: CYP3A4 interactions; do not combine with pimozide, terfenadine, astemizole or cisapride; lower oral dexamethasone and methylprednisolone doses; check INR in warfarin users; advise alternative contraception during and for 28 days after use; limited data in severe hepatic impairment
• Storage: below 30°C; protect from moisture
• Manufactured and marketed in Pakistan by: Pharmasol (Pvt) Ltd
• Pack: 3-day pack of one 125mg capsule and two 80mg capsules

Frequently asked questions

What is Nautant 125mg used for?

It prevents nausea and vomiting caused by chemotherapy, both on treatment day and over the next two days. Doctors give it with a steroid and another anti-sickness medicine.

What is the Nautant 125mg price in Pakistan?

Nautant 125mg costs Rs 1,500 per pack. Prices can change with supply, so message us on WhatsApp for today’s price before you order.

Is Nautant 125mg available in Lahore, Karachi or Peshawar?

Yes. We deliver nationwide, including Islamabad, Rawalpindi, Lahore, Karachi, Peshawar, Multan and Faisalabad.

Do I need a prescription to buy Nautant 125mg?

Yes. Your oncologist prescribes it as part of your chemotherapy plan. Share a photo of the prescription on WhatsApp, and our pharmacist confirms it before we send the pack.

How do I take the Nautant 125mg pack?

Take the 125mg capsule on the day of chemotherapy and the 80mg capsules on the following days, as your doctor directs. Swallow them whole, with or without food.

What is inside a Nautant 125mg pack?

Each pack holds three capsules: one 125mg capsule and two 80mg capsules. Together they make one full three-day course for a single chemotherapy cycle.

What is the difference between Nautant 125mg and Nautant 80mg?

The 125mg pack is the complete starter course for one cycle. The 80mg pack contains only the two follow-on capsules, for patients whose doctor asks for them separately.

Can I order Nautant 125mg for my mother or father from abroad?

Yes. Families in the UAE, UK and Saudi Arabia order through MedHub for parents in Pakistan. Send the prescription and chemotherapy date on WhatsApp, and we plan delivery around it.

Last updated: 3 October 2026

This information is for general awareness only and is not medical advice. Always consult your doctor before starting, stopping or changing any medicine.