Glynib® 400mg Tablets (Imatinib) – Targeted Therapy (Rx)

Quick answer: Glynib 400mg (imatinib) is a Pakistani-made targeted tablet that adults take by mouth for chronic myeloid leukaemia (CML) and gastrointestinal stromal tumours (GIST). One tablet holds the usual adult daily strength. MedHub supplies it on prescription and delivers it to any city in Pakistan.

For patients and families

What is Glynib 400mg?

Glynib 400mg is an imatinib tablet manufactured and marketed by Pharmasol (Pvt) Ltd in Pakistan. In CML, a gene swap between two chromosomes creates an overactive enzyme called BCR-ABL. In GIST, a similar enzyme called KIT is switched on. Imatinib blocks these enzymes, so the cancer cells lose the signal that keeps them dividing and many of them die.

What is it used for?

Doctors in Pakistan most often prescribe it for CML and GIST. The full list of approved uses is:

• Philadelphia chromosome-positive chronic myeloid leukaemia, in chronic, accelerated or blast phase
• KIT-positive GIST that has spread or cannot be removed, and after surgery to reduce the risk of return
• Philadelphia-positive acute lymphoblastic leukaemia
• Hypereosinophilic syndrome, systemic mastocytosis and some myeloproliferative disorders
• Dermatofibrosarcoma protuberans, a rare skin tumour

If you need a reduced or children’s dose, your doctor may switch you to Glynib 100mg capsules.

How is it taken?

Take Glynib 400mg with food, never on an empty stomach, and wash it down with a full glass of water. Your doctor or pharmacist explains when to take it and what to do if you miss a tablet. Your doctor decides the dose and may change it depending on your blood results. Results take time, so steady daily use matters more than anything else. Tell every doctor, dentist and pharmacist you see that you take imatinib.

Common side effects

• Swelling, often first seen as puffy eyelids in the morning
• Leg cramps and muscle or bone aches
• Nausea and diarrhoea
• Itchy skin or a rash
• Anaemia and low white cells, picked up on blood tests

Speak to your doctor straight away about rapid weight gain, breathlessness when lying flat, jaundice, a fever with chills, or any bleeding that does not stop.

Storage

Keep the strip in its box below 30°C and away from humidity and direct sun. Never leave the tablets in a parked car, and keep them out of children’s reach.

How to order from MedHub

1. Send a photo of your prescription on WhatsApp.
2. Our pharmacist confirms the price and stock with you.
3. We pack the tablets and deliver them to your city.

Many patients on long-term imatinib rely on relatives in the UAE, UK or Saudi Arabia, who order Glynib 400mg through us every month. We also supply Imatigliv 400mg (imatinib) and Hydroxa 500mg (hydroxyurea), which some doctors use to control high blood counts. Browse our full oncology section for more.

For healthcare professionals

• Composition: imatinib 400 mg (as imatinib mesylate) per tablet
• Drug class: signal transduction inhibitor, BCR-ABL tyrosine kinase inhibitor
• Indications: Ph+ CML (chronic phase newly diagnosed or after interferon failure, accelerated phase, blast crisis); Ph+ ALL; PDGFR-rearranged MDS/MPD; aggressive systemic mastocytosis; HES/CEL; DFSP; Kit (CD117)-positive unresectable or metastatic GIST; adjuvant therapy after GIST resection
• Mechanism: inhibits the constitutively active BCR-ABL kinase as well as the KIT and PDGFR receptor kinases, inducing apoptosis in BCR-ABL-positive and KIT-driven cells
• Label dose: CML chronic phase 400 mg once daily (may increase to 600 mg); accelerated phase or blast crisis 600 mg once daily (may increase to 800 mg as 400 mg twice daily); GIST 400 mg daily, adjuvant for 3 years; MDS/MPD and ASM 400 mg daily; taken with a meal and a large glass of water
• Monitoring / key precautions: CBC weekly for 1 month, biweekly for the second month, then every 2–3 months; LFTs monthly or as indicated; check for oedema and fluid retention; left ventricular dysfunction in patients at risk; hepatitis B testing; GI perforation and haemorrhage risk in GIST; CYP3A4 drug interactions; embryo-fetal toxicity
• Storage: below 30°C, protect from moisture
• Manufactured and marketed in Pakistan by: Pharmasol (Pvt) Ltd
• Pack: 30 tablets

Frequently asked questions

What does Glynib 400mg treat?

Glynib 400mg treats chronic myeloid leukaemia and gastrointestinal stromal tumours in adults. Doctors may also use it for Philadelphia-positive ALL and several rare blood and skin conditions.

What is the Glynib 400mg price in Pakistan?

Glynib 400mg costs Rs 41,000 per pack of 30 tablets. Prices can change with supply, so message us on WhatsApp for today’s price before you order.

Do you deliver Glynib 400mg in Lahore, Karachi or Peshawar?

Yes. We deliver Glynib 400mg to Islamabad, Rawalpindi, Lahore, Karachi, Peshawar, Multan, Faisalabad and other cities across the country.

Can I buy Glynib 400mg without a prescription?

No. Imatinib is a prescription-only medicine, so we need a valid prescription from your cancer specialist. Send a clear photo on WhatsApp to start your order.

What should I do if I miss a dose of Glynib 400mg?

Do not take two doses together to make up for it. Ask your doctor or pharmacist what to do, and keep a simple daily reminder to avoid gaps.

How is Glynib 400mg different from Glynib 100mg?

Both contain imatinib from the same maker. The 400mg tablet suits adults on the standard daily dose, while the 100mg capsules suit children and patients whose dose has been lowered or split.

How should Glynib 400mg be stored?

Store the tablets below 30°C in their original pack, protected from moisture and sunlight.

Can I order Glynib 400mg from abroad for my parents?

Yes. Families in the UAE, UK and Saudi Arabia order through MedHub regularly. Send us the prescription on WhatsApp, and we arrange payment and delivery to your parents’ home in Pakistan.

Last updated: 3 October 2026

This information is for general awareness only and is not medical advice. Always consult your doctor before starting, stopping or changing any medicine.