Gazyva® 1000mg/40ml Injection (Obinutuzumab) – Targeted Therapy (Rx)

Quick answer: Gazyva 1000mg/40ml contains obinutuzumab, a targeted antibody for chronic lymphocytic leukaemia (CLL) and follicular lymphoma. A nurse gives it as a slow drip into a vein at a hospital or day-care unit. MedHub supplies it on prescription and delivers it in cold-chain packaging to every city in Pakistan.

For patients and families

What is Gazyva 1000mg?

Gazyva is Roche’s brand of obinutuzumab. It is a monoclonal antibody, a laboratory-made protein that locks onto a marker called CD20 on certain white blood cells and helps your immune system destroy them. Each vial holds 1000mg in 40ml of concentrate, and the hospital pharmacy dilutes it before your infusion.

What is it used for?

Blood cancer specialists prescribe Gazyva for two conditions:

• Chronic lymphocytic leukaemia (CLL): given together with chemotherapy, usually for patients starting treatment for the first time.
• Follicular lymphoma: a slow-growing type of non-Hodgkin lymphoma. Doctors give Gazyva with chemotherapy first and then on its own as maintenance.

Your doctor decides whether Gazyva suits you after looking at your diagnosis, blood tests and earlier treatment.

How is it given?

A nurse gives Gazyva as a drip (infusion) into a vein. The first infusions take several hours, and the team watches you closely because reactions happen most often at the start. You usually receive medicines beforehand to lower the chance of a reaction. Your doctor decides the dose and the number of cycles.

Before treatment starts, your doctor tests your blood for hepatitis B, because obinutuzumab can reactivate an old infection.

Common side effects

• A reaction during the drip, such as fever, chills, flushing or breathlessness
• Low white cell or platelet counts, which raise the risk of infection or bleeding
• Coughs, colds and other infections
• Tiredness and loose stools

Tell your care team straight away if you develop a fever, unusual bruising or bleeding, yellow skin or eyes, or new confusion and problems with balance or eyesight.

Storage

Keep the vial in its box in the fridge at 2–8°C to protect it from light, and never freeze it. Most hospitals store it for you. If you collect it yourself, carry it in a cool bag with ice packs. Read more about how we keep medicines cold during delivery.

How to order from MedHub

1. Send a photo of your prescription on WhatsApp.
2. Our pharmacist confirms the price and stock with you.
3. We pack the vial in a cold-chain box and deliver it to your city or hospital.

Families in the UAE, UK and Saudi Arabia often arrange Gazyva for parents in Pakistan through us. You can also look at Ristova 500mg (rituximab), another anti-CD20 antibody, or browse our hematology and oncology medicines.

For healthcare professionals

• Composition: obinutuzumab 1000 mg/40 ml (25 mg/ml) concentrate for solution for infusion
• Drug class: glycoengineered type II anti-CD20 humanized IgG1 monoclonal antibody
• Indications: previously untreated CLL in combination with chlorambucil; previously untreated advanced follicular lymphoma with chemotherapy, followed by maintenance in responders; follicular lymphoma that relapsed on or is refractory to a rituximab-containing regimen, with bendamustine, followed by maintenance
• Mechanism: binds CD20 on pre-B and mature B lymphocytes, with enhanced antibody-dependent cellular cytotoxicity and direct cell death compared with type I anti-CD20 antibodies
• Label dose (CLL): cycle 1: 100 mg on day 1, 900 mg on day 2, 1000 mg on days 8 and 15; cycles 2–6: 1000 mg on day 1 (28-day cycles)
• Label dose (follicular lymphoma): 1000 mg on days 1, 8 and 15 of cycle 1, then on day 1 of each later induction cycle; maintenance 1000 mg every 2 months for 2 years
• Before and during treatment: premedicate with a corticosteroid, antihistamine and antipyretic as per label; screen for hepatitis B; monitor blood counts; consider tumour lysis prophylaxis in patients with a high tumour burden
• Storage: 2–8°C in the outer carton to protect from light; do not freeze
• Manufacturer: F. Hoffmann-La Roche Ltd, Switzerland
• Marketed in Pakistan by: Roche Pakistan Ltd
• Pack: 1 vial of 40 ml

Frequently asked questions

What is Gazyva 1000mg used for?

Gazyva 1000mg treats chronic lymphocytic leukaemia (CLL) and follicular lymphoma, a type of non-Hodgkin lymphoma. Doctors combine it with chemotherapy, and in follicular lymphoma they may continue it alone as maintenance.

What is the Gazyva 1000mg price in Pakistan?

Gazyva 1000mg/40ml costs Rs 173,240 per vial. Prices can change with supply, so message us on WhatsApp for today’s price before you order.

Can I get Gazyva 1000mg in Lahore, Karachi or Peshawar?

Yes. MedHub delivers Gazyva across Pakistan, including Islamabad, Rawalpindi, Lahore, Karachi, Peshawar, Multan and Faisalabad. We pack every vial in a cold-chain box to keep it at 2–8°C on the way.

Do I need a prescription to buy Gazyva 1000mg?

Yes. Gazyva is a prescription-only medicine. Send a clear photo of your specialist’s prescription on WhatsApp, and our pharmacist checks it before confirming your order.

How is Gazyva 1000mg given?

A nurse gives Gazyva as a slow drip into a vein at a hospital or day-care unit. The first infusions take several hours, and you receive medicines beforehand to reduce the chance of a reaction.

What is the difference between Gazyva 1000mg and rituximab?

Both medicines target the CD20 marker on B cells. Gazyva (obinutuzumab) is a newer, engineered antibody built to trigger a stronger immune attack on these cells. Your specialist decides which one suits your disease and earlier treatment.

How should Gazyva 1000mg be stored?

Store Gazyva in its original box in the fridge at 2–8°C and never freeze it. Carry it to the hospital in a cool bag with ice packs, and keep the vial from touching the ice directly.

Can I order Gazyva 1000mg for my parents in Pakistan from abroad?

Yes. Many families in the UAE, UK and Saudi Arabia order Gazyva through MedHub for parents in Pakistan. Share the prescription on WhatsApp, and our team guides you through payment and delivery to their home or hospital.

Last updated: 3 October 2026

This information is for general awareness only and is not medical advice. Always consult your doctor before starting, stopping or changing any medicine.