Trexate® 10mg Tablets (Methotrexate) – Chemotherapy (Rx)

Quick answer: Trexate 10mg (methotrexate) is a higher-strength tablet used for rheumatoid arthritis, severe psoriasis and certain blood cancers. People with arthritis or psoriasis take it on one fixed day each week, not daily. MedHub supplies it against a valid prescription and delivers throughout Pakistan.

For patients and families

What is Trexate 10mg?

Trexate 10mg contains methotrexate, a medicine Pharmasol makes in Pakistan. It interferes with the way fast-growing cells use folic acid. In cancer care this slows the spread of abnormal cells. In inflammatory conditions, smaller amounts quieten the immune reaction that attacks the joints or skin. This strength suits people whose doctor has set a larger weekly amount, as it means swallowing fewer tablets.

What is it used for?

Methotrexate has a long track record across these conditions:

• Severe psoriasis that has not settled with other treatment
• Rheumatoid arthritis, and some types of juvenile arthritis
• Acute lymphoblastic leukaemia, during the maintenance phase
• Non-Hodgkin lymphoma, including lymphoma of the skin, and some rare tumours linked to pregnancy

A rheumatologist, dermatologist or oncologist chooses this treatment after reviewing your blood counts, liver and kidney tests.

How is it taken?

Your doctor or pharmacist explains how to take it. For psoriasis and rheumatoid arthritis, the doctor sets a weekly schedule, with all of that week’s tablets taken on the same day. Taking methotrexate daily instead of weekly is a dangerous mistake that can lead to hospital admission or death. If you are unsure of your day, stop and ask before taking another tablet.

Your doctor decides the dose. Because a pack of 10mg looks much like a pack of the lower strength, always check the strength on the box when a new supply arrives.

Common side effects

• Feeling sick around the day of the dose
• Sore mouth or small ulcers
• Raised liver enzymes on blood tests
• Tiredness, dizziness or headache
• Mild hair loss

Seek help straight away if you notice a fever, chills or sore throat, bleeding gums or easy bruising, a cough with breathlessness, dark urine or yellowing of the skin.

Storage

Keep the pack below 30°C, in a dry cupboard and well away from children. Do not move the tablets into a pill box that holds daily medicines.

How to order from MedHub

1. Send a photo of your prescription on WhatsApp.
2. Our pharmacist confirms the price and stock with you.
3. We send the tablets to your door, wherever you live in Pakistan.

Sons and daughters working in the UAE, UK and Saudi Arabia regularly order Trexate 10mg for parents in Pakistan through MedHub. For smaller weekly amounts, doctors often prescribe Trexate 2.5mg tablets. Hospitals running high-dose protocols use Trexate 1000mg/40ml injection, and our full range sits under oncology medicines.

For healthcare professionals

• Composition: methotrexate 10 mg per tablet
• Drug class: folate antagonist antimetabolite; conventional synthetic DMARD
• Indications: acute lymphoblastic leukaemia (maintenance therapy within combination regimens); non-Hodgkin lymphoma, including mycosis fungoides; gestational trophoblastic neoplasia; severe active rheumatoid arthritis and polyarticular juvenile idiopathic arthritis; severe recalcitrant psoriasis
• Mechanism: competitive inhibition of dihydrofolate reductase reduces tetrahydrofolate, blocking purine and thymidylate synthesis
• Label dose: rheumatoid arthritis, start at 7.5 mg once weekly and titrate, usually to no more than 20 mg once weekly; psoriasis 10–25 mg as a single weekly dose; malignancy as per protocol. State the weekly day and the tablet strength on every prescription
• Monitoring / key precautions: FBC, LFTs and creatinine at baseline and regularly during treatment; give folic acid; interactions with trimethoprim, co-trimoxazole, NSAIDs, PPIs and penicillins; contraindicated in pregnancy, breastfeeding, significant renal or hepatic impairment and pre-existing blood dyscrasias; risk of pneumonitis, serious infections and skin reactions; no live vaccines
• Storage: below 30°C; protect from moisture
• Manufactured and marketed in Pakistan by: Pharmasol (Pvt) Ltd
• Pack: 100 tablets

Frequently asked questions

What conditions does Trexate 10mg treat?

Trexate 10mg treats severe psoriasis, rheumatoid arthritis, acute lymphoblastic leukaemia and some lymphomas. Your prescriber chooses the schedule according to which condition you have.

What is the Trexate 10mg price in Pakistan?

Trexate 10mg costs Rs 3,600 per pack of 100 tablets. Prices can change with supply, so message us on WhatsApp for today’s price before you order.

Is Trexate 10mg available in Lahore, Karachi or Peshawar?

Yes. We deliver to Islamabad, Rawalpindi, Lahore, Karachi, Peshawar, Multan, Faisalabad and other cities across Pakistan.

Can I buy Trexate 10mg without a prescription?

No. Methotrexate needs a doctor’s prescription and regular blood tests. Share a photo of the prescription on WhatsApp so our pharmacist can check it.

Who usually needs Trexate 10mg rather than 2.5mg?

People whose doctor has prescribed a larger weekly amount often use the 10mg strength, so they swallow fewer tablets. Both strengths contain the same medicine. Never swap between them without your doctor’s instruction.

What happens if I take Trexate 10mg every day by mistake?

Taking weekly methotrexate daily can cause a dangerous overdose. Contact your doctor or the nearest emergency department immediately, even if you feel well, because there is an antidote that works best when given early.

How should Trexate 10mg be stored?

Store it below 30°C in its original box, protected from damp. Keep it separate from your daily medicines so the weekly tablets never get mixed in.

Can I send Trexate 10mg to my parents in Pakistan from abroad?

Yes. You can order from the UAE, UK, Saudi Arabia or anywhere else. Send us the prescription on WhatsApp, our team arranges payment, and we deliver to your parents’ home.

Last updated: 3 October 2026

This information is for general awareness only and is not medical advice. Always consult your doctor before starting, stopping or changing any medicine.