Trexate® 2.5mg Tablets (Methotrexate) – Chemotherapy (Rx)

Quick answer: Trexate 2.5mg (methotrexate) is a tablet that doctors prescribe for rheumatoid arthritis, severe psoriasis and some leukaemias and lymphomas. For arthritis and psoriasis it is taken just once a week, never every day. MedHub supplies it on prescription and delivers to every city in Pakistan.

For patients and families

What is Trexate 2.5mg?

Trexate 2.5mg is a tablet of methotrexate made in Pakistan by Pharmasol. Methotrexate slows down cells that divide quickly. At higher doses it holds back cancer cells, and at the much lower doses used for arthritis and psoriasis it calms an overactive immune system. Each pack holds 100 tablets.

What is it used for?

Doctors from several specialities prescribe this medicine:

• Rheumatoid arthritis: to ease joint pain and swelling and slow joint damage, including some forms of arthritis in children.
• Severe psoriasis: when creams and light treatment have not controlled the skin.
• Acute lymphoblastic leukaemia: as part of long-term maintenance treatment.
• Some lymphomas and other cancers: including mycosis fungoides, a lymphoma of the skin, and certain pregnancy-related tumours.

Your doctor decides whether methotrexate suits you after checking your blood tests, kidneys and liver.

How is it taken?

You swallow Trexate 2.5mg tablets with water. For rheumatoid arthritis and psoriasis, your doctor sets a weekly schedule: you take your dose on one chosen day of the week, such as every Monday, and take none on the other six days. Taking methotrexate daily by mistake is dangerous and has caused serious harm and deaths. Write the day on your calendar or set a phone reminder.

Cancer schedules differ, and your oncologist explains yours. Your doctor decides the dose, and most people on weekly methotrexate also take folic acid on a different day to reduce side effects.

Common side effects

• Nausea or a poor appetite for a day after the weekly dose
• Mouth ulcers
• Tiredness or mild headache
• Some thinning of the hair
• Changes in liver blood tests

Contact your doctor straight away if you get a sore throat or fever, unusual bruising or bleeding, a new dry cough or breathlessness, yellow skin or eyes, or severe mouth sores.

Storage

Store the tablets below 30°C in the original pack, away from damp and out of reach of children. Carers should wash their hands after handling them.

How to order from MedHub

1. Send a photo of your prescription on WhatsApp.
2. Our pharmacist confirms the price and stock with you.
3. We deliver the pack to your home or clinic anywhere in Pakistan.

Many families in the UAE, UK and Saudi Arabia arrange Trexate 2.5mg for a parent back home through us. If your doctor prescribes a higher weekly amount, ask about Trexate 10mg tablets. Hospitals that need the injectable form can order Trexate 50mg/2ml injection, and you can browse all our oncology medicines.

For healthcare professionals

• Composition: methotrexate 2.5 mg per tablet
• Drug class: antimetabolite, folic acid antagonist; disease-modifying antirheumatic drug
• Indications: acute lymphoblastic leukaemia (maintenance, as part of combination regimens); non-Hodgkin lymphoma and mycosis fungoides; gestational trophoblastic neoplasia; severe active rheumatoid arthritis, including polyarticular juvenile idiopathic arthritis; severe, disabling psoriasis not responding to other therapy
• Mechanism: inhibits dihydrofolate reductase, blocking DNA synthesis and cell replication; anti-inflammatory effects at low doses include adenosine release
• Label dose: rheumatoid arthritis 7.5 mg once weekly, adjusted to response, usually not above 20 mg once weekly; psoriasis 10–25 mg once weekly; oncology doses follow the treatment protocol. Prescriptions must state the weekly day clearly
• Monitoring / key precautions: baseline and regular full blood count, liver and renal function; folic acid supplementation; avoid co-trimoxazole and trimethoprim, and use NSAIDs with care; contraindicated in pregnancy and breastfeeding, severe renal or hepatic impairment and blood dyscrasias; watch for pneumonitis; avoid live vaccines
• Storage: below 30°C, protected from moisture
• Manufactured and marketed in Pakistan by: Pharmasol (Pvt) Ltd
• Pack: 100 tablets

Frequently asked questions

What is Trexate 2.5mg used for?

Trexate 2.5mg treats rheumatoid arthritis, severe psoriasis, acute lymphoblastic leukaemia and some lymphomas. The same tablet serves very different conditions, so the schedule depends on why your doctor prescribed it.

What is the Trexate 2.5mg price in Pakistan?

Trexate 2.5mg costs Rs 1,200 per pack of 100 tablets. Prices can change with supply, so message us on WhatsApp for today’s price before you order.

Can I get Trexate 2.5mg in Lahore, Karachi or Peshawar?

Yes. MedHub delivers across Pakistan, including Islamabad, Rawalpindi, Lahore, Karachi, Peshawar, Multan and Faisalabad.

Do I need a prescription to buy Trexate 2.5mg?

Yes. Methotrexate is a prescription-only medicine because it needs regular blood tests. Send a clear photo of your prescription on WhatsApp, and our pharmacist checks it before confirming your order.

Why is Trexate 2.5mg taken once a week and not daily?

For arthritis and psoriasis, the weekly schedule gives your body six days to recover between doses. Taking the tablets every day by mistake can damage the bone marrow, liver and gut, so call your doctor at once if this happens.

Should I take folic acid with Trexate 2.5mg?

Most people on weekly methotrexate do take folic acid, which lowers the risk of mouth ulcers, nausea and liver changes. Your doctor tells you which day to take it, usually not the same day as your methotrexate.

Is Trexate 2.5mg safe in pregnancy?

No. Methotrexate can harm an unborn baby. Women and men taking it should use reliable contraception and speak to their doctor well before planning a pregnancy, as the medicine needs time to leave the body.

Can I order Trexate 2.5mg for my parents in Pakistan from abroad?

Yes. Families in the UAE, UK and Saudi Arabia often order through MedHub for parents in Pakistan. Share the prescription on WhatsApp, and our team arranges payment and delivery to their home.

Last updated: 3 October 2026

This information is for general awareness only and is not medical advice. Always consult your doctor before starting, stopping or changing any medicine.