Trexate® 50mg/2ml Injection (Methotrexate) – Chemotherapy (Rx)

Quick answer: Trexate 50mg (methotrexate) is a 2ml vial of chemotherapy used for leukaemia, lymphoma, breast cancer, head and neck cancer and some rare tumours, and for severe psoriasis and rheumatoid arthritis. A nurse or doctor gives it by injection. MedHub supplies it on prescription with delivery across Pakistan.

For patients and families

What is Trexate 50mg?

Trexate 50mg is a ready-made solution of methotrexate, 50mg in a 2ml vial, produced in Pakistan by Pharmasol. Methotrexate is one of the oldest chemotherapy medicines still in daily use. It blocks an enzyme that cells need to copy their DNA, so cancer cells that divide quickly stop growing.

What is it used for?

Specialists use methotrexate injection, alone or with other medicines, for:

• Acute lymphoblastic leukaemia, including treatment that protects the brain and spinal cord
• Non-Hodgkin lymphoma and lymphoma affecting the skin
• Breast cancer and squamous cell cancers of the head and neck
• Gestational trophoblastic disease, a rare tumour that grows from pregnancy tissue
• Severe psoriasis and rheumatoid arthritis, when other treatment has not worked

Your specialist looks at your diagnosis, kidney function and blood counts before choosing this treatment.

How is it given?

Trained hospital staff give Trexate 50mg as an injection into a muscle or a vein, or diluted in a drip. The route and timing depend on your condition and your treatment plan. Your doctor decides the dose, and the pharmacy may draw from more than one vial to prepare it.

For psoriasis and arthritis, methotrexate is given once a week only. Drink plenty of fluids on treatment days unless your team tells you otherwise.

Common side effects

• Mouth ulcers and a sore throat
• Nausea, vomiting or loss of appetite
• Low blood counts, which make infections more likely
• Tiredness and feeling generally unwell
• Skin that burns easily in the sun

Tell your care team at once about a temperature above 38°C, bleeding or bruising, blood in your urine, breathlessness, a dry cough, or diarrhoea that does not settle.

Storage

Store the vial below 25°C in its carton so light cannot reach it. The hospital pharmacy usually keeps and prepares it, so you rarely need to store it at home.

How to order from MedHub

1. Send a photo of your prescription on WhatsApp.
2. Our pharmacist confirms the price and stock with you.
3. We pack the vials with care and deliver them to your hospital or home.

Families in the UAE, UK and Saudi Arabia regularly arrange Trexate 50mg for a mother or father in Pakistan through us. Protocols that need much larger amounts use Trexate 1000mg/40ml, and for treatment at home your doctor may switch you to Trexate 2.5mg tablets. Leukaemia patients often also need Cytorox 500mg (cytarabine).

For healthcare professionals

• Composition: methotrexate 50 mg/2 ml (25 mg/ml) solution for injection
• Drug class: antimetabolite antineoplastic, folic acid antagonist
• Indications: acute lymphoblastic leukaemia, including prophylaxis and treatment of meningeal leukaemia; non-Hodgkin lymphoma and mycosis fungoides; breast cancer; squamous cell carcinoma of the head and neck; gestational trophoblastic neoplasia; osteosarcoma (high-dose regimens with folinic acid rescue); severe psoriasis and severe active rheumatoid arthritis
• Mechanism: inhibits dihydrofolate reductase, depleting reduced folates and halting DNA synthesis in the S phase
• Label dose: highly regimen-dependent; psoriasis 10–25 mg IM or IV once weekly; rheumatoid arthritis 7.5–25 mg once weekly; oncology doses per protocol. Intrathecal use only with a preservative-free formulation, so confirm the product label before that route
• Monitoring / key precautions: FBC, renal and liver function before each dose; dose adjustment in renal impairment; folinic acid rescue for doses above the low range; avoid NSAIDs, PPIs, co-trimoxazole and other interacting drugs around high doses; caution with pleural effusions or ascites; contraindicated in pregnancy
• Storage: below 25°C, protected from light
• Manufactured and marketed in Pakistan by: Pharmasol (Pvt) Ltd
• Pack: 1 vial

Frequently asked questions

What is Trexate 50mg used for?

Trexate 50mg treats leukaemia, lymphoma, breast cancer, head and neck cancer and gestational trophoblastic disease. Doctors also use it once a week for severe psoriasis and rheumatoid arthritis.

What is the Trexate 50mg price in Pakistan?

Trexate 50mg costs Rs 350 per vial. Prices can change with supply, so message us on WhatsApp for today’s price before you order.

Do you deliver Trexate 50mg to Lahore, Karachi or Peshawar?

Yes. We deliver to hospitals and homes in Islamabad, Rawalpindi, Lahore, Karachi, Peshawar, Multan and Faisalabad, and to other cities on request.

Is a prescription needed for Trexate 50mg?

Yes. It is a prescription-only chemotherapy injection. Send your specialist’s prescription on WhatsApp, and our pharmacist reviews it before we confirm the order.

How is Trexate 50mg given?

A nurse or doctor injects it into a muscle or a vein, or gives it diluted in a drip. You receive it at a hospital or clinic, where the team checks your blood tests first.

How many Trexate 50mg vials will I need?

That depends on the dose your doctor prescribes. Some patients need part of one vial, while others need several. The hospital pharmacist tells you the exact number before you order.

Is Trexate 50mg the same medicine as the tablets?

Yes, both contain methotrexate. The injection reaches the blood more reliably and suits larger doses or patients who cannot take tablets, but you should not switch forms without your doctor’s advice.

Can I order Trexate 50mg for a parent in Pakistan while living abroad?

Yes. Share the prescription with us on WhatsApp from the UAE, UK, Saudi Arabia or elsewhere. Our team arranges payment and delivers to the hospital treating your parent.

Last updated: 3 October 2026

This information is for general awareness only and is not medical advice. Always consult your doctor before starting, stopping or changing any medicine.