Ristova® 100mg/10ml Injection (Rituximab) – Targeted Therapy (Rx)

Quick answer: Ristova 100mg (rituximab) is a 10ml vial of Roche’s targeted antibody used for B-cell lymphomas, CLL, rheumatoid arthritis and some forms of vasculitis. The hospital adds it to an infusion bag and a nurse gives it into a vein. MedHub supplies it on prescription, with cold-chain delivery to any city in Pakistan.

Patient and caregiver information

What is Ristova 100mg?

Ristova 100mg is the smaller vial of Roche’s rituximab. It contains 100mg of medicine in 10ml, the same strength per millilitre as the larger 500mg vial. Doctors rarely use it on its own. Instead, the pharmacy adds one or more of these vials to larger ones to reach the exact amount your doctor has worked out for you, so very little medicine goes to waste.

Rituximab is a laboratory-made antibody. It finds a protein called CD20 on B cells and marks them for removal by the immune system. Before the first infusion, your doctor tests your blood for hepatitis B, because rituximab can reactivate a hidden infection.

What is it used for?

Rituximab has approval for:

• Follicular lymphoma and diffuse large B-cell lymphoma, two types of non-Hodgkin lymphoma
• Chronic lymphocytic leukaemia, together with chemotherapy
• Rheumatoid arthritis that has not settled with other biological treatment, given with methotrexate
• Granulomatosis with polyangiitis and microscopic polyangiitis, rare inflammatory diseases of the blood vessels
• Moderate to severe pemphigus vulgaris, a blistering skin disease

Your specialist chooses the treatment plan based on your test results and earlier treatment.

How is it given?

Ristova 100mg is given by trained healthcare staff in a hospital or clinic, as an injection or infusion. Your doctor decides the dose and the treatment schedule.

Common side effects

• Fever, shivering or rash during or soon after the drip
• More frequent colds, sinus or chest infections
• A drop in white blood cells
• Feeling tired or achy

Report any swelling of the lips or face, wheezing, a temperature, dark urine or yellow eyes, skin blisters, or sudden memory or speech problems to your doctor without delay.

Storage and transportation

Transportation of cold-chain products must go through the dispensing pharmacy and follow the manufacturer’s instructions. Ask your dispensing pharmacist if you have any questions about handling.

How to order from MedHub

1. Send a photo of your prescription on WhatsApp.
2. Our pharmacist confirms the price and stock with you.
3. We deliver the vial in a cold-chain box to your home or hospital.

Many sons and daughters living in the UAE, UK and Saudi Arabia order Ristova 100mg for a family member’s treatment in Pakistan. Most prescriptions pair it with Ristova 500mg/50ml. We also stock Rituxim 100mg/10ml (rituximab), and the full range sits under oncology medicines.

For healthcare professionals

• Composition: rituximab 100 mg/10 ml (10 mg/ml) concentrate for solution for infusion
• Drug class: chimeric anti-CD20 IgG1 kappa monoclonal antibody
• Indications: follicular lymphoma (first line with chemotherapy, maintenance, and relapsed or chemoresistant disease as monotherapy); CD20-positive diffuse large B-cell lymphoma with CHOP; CLL with chemotherapy; severe active rheumatoid arthritis with methotrexate after TNF inhibitor failure; GPA and MPA with glucocorticoids; moderate to severe pemphigus vulgaris
• Mechanism: targets the CD20 antigen on B lymphocytes and depletes them through complement-dependent and antibody-dependent cytotoxicity and induction of apoptosis
• Label dose: 375 mg/m² per administration in NHL regimens; CLL 375 mg/m² cycle 1 and 500 mg/m² cycles 2–6; rheumatoid arthritis 1000 mg on days 1 and 15; GPA/MPA 375 mg/m² once weekly for 4 doses
• Monitoring / key precautions: dilute to 1–4 mg/ml in 0.9% sodium chloride or 5% glucose; premedication before each infusion; first infusion starts at 50 mg/h; hepatitis B screening; watch for cytokine release, tumour lysis syndrome, cardiac arrhythmias, PML and severe skin reactions; monitor neutrophil counts; no live vaccines during B-cell depletion
• Storage: refrigerate at 2–8°C, protect from light, do not freeze
• Manufacturer: F. Hoffmann-La Roche Ltd, Switzerland
• Marketed in Pakistan by: Roche Pakistan Ltd
• Pack: 1 vial (10 ml)

Frequently asked questions

What is Ristova 100mg?

Ristova 100mg is the smaller vial of Roche's rituximab.

What is Ristova 100mg used for?

Ristova 100mg is used in the treatment of follicular lymphoma and diffuse large B-cell lymphoma, chronic lymphocytic leukaemia, rheumatoid arthritis that has not settled with other biological treatment, granulomatosis with polyangiitis and microscopic polyangiitis and moderate to severe pemphigus vulgaris. Your doctor decides whether it suits your condition.

How is Ristova 100mg given?

Ristova 100mg is given by trained healthcare staff in a hospital or clinic, as an injection or infusion. Your doctor decides the dose and the treatment schedule.

How does Ristova 100mg work?

Ristova 100mg is a laboratory-made antibody given into a vein. It travels through the bloodstream and attaches to a marker called CD20 on the surface of B cells. This flags the B cells, including cancerous ones in lymphoma and leukaemia, so the immune system can destroy them. In rheumatoid arthritis, lowering the number of B cells calms the immune attack on the joints.

What precautions should I know before using Ristova 100mg?

Before treatment, tell your doctor about any current infection, past hepatitis B, heart or lung disease, and blood pressure medicines. Hepatitis B can become active again, so you will be tested first. Avoid live vaccines during and after treatment. Use effective contraception for 12 months after the last dose. Report straight away fever, chills, rash or breathing trouble during the infusion, blistering skin or mouth sores, signs of infection, or new confusion or vision changes.

What is the Ristova 100mg price in Pakistan?

Ristova 100mg costs Rs 21,560 per vial. Contact MedHub to confirm current price, availability and delivery options.

Can I get Ristova 100mg in Lahore, Karachi or Peshawar?

Yes. MedHub serves patients across Pakistan, including Islamabad, Rawalpindi, Lahore, Karachi, Peshawar, Multan and Faisalabad. Contact MedHub to confirm current price, availability and delivery options.

Do I need a prescription to buy Ristova 100mg?

Yes. Ristova 100mg is a prescription-only medicine. Send a clear photo of your doctor's prescription on WhatsApp, and our pharmacist checks it before confirming your order.

Can I order Ristova 100mg for my family in Pakistan from abroad?

Yes. People in the UAE, UK and Saudi Arabia order Ristova 100mg through MedHub for their family in Pakistan. Share the prescription on WhatsApp, and our team guides you through payment and delivery to their home or hospital.

Sources: FDA prescribing information for healthcare professionals; FDA patient leaflet for patients and caregivers. MedHub writes its own plain-language summaries. Always read the leaflet supplied with your medicine.

This information is for general awareness only and is not medical advice. Always consult your doctor before starting, stopping or changing any medicine.