Nilosigna® 200mg Capsules (Nilotinib) – Targeted Therapy (Rx)

Quick answer: Nilosigna 200mg (nilotinib) is a targeted capsule for Philadelphia chromosome-positive chronic myeloid leukaemia (CML). Patients swallow it at home on an empty stomach, under the care of a blood cancer specialist. MedHub supplies it on prescription and delivers it to every city in Pakistan.

For patients and families

What is Nilosigna 200mg?

Nilosigna 200mg is a hard capsule that contains nilotinib, and Oncogen Pharma markets it in Pakistan. Nilotinib belongs to a family of medicines called tyrosine kinase inhibitors. In CML, a faulty gene called BCR-ABL tells the bone marrow to make too many abnormal white cells. Nilotinib switches off the signal from that gene, so blood counts can return towards normal.

What is it used for?

Haematologists prescribe Nilosigna 200mg for Philadelphia chromosome-positive CML in two main situations:

• Newly diagnosed CML in the chronic phase: as the first targeted treatment.
• CML that did not respond to earlier treatment: in the chronic or accelerated phase, when imatinib stopped working or caused side effects the patient could not manage.

Doctors also use nilotinib for children aged one year and older with chronic-phase CML. Your specialist confirms the diagnosis with blood and bone marrow tests, including a test for the BCR-ABL gene, before starting treatment.

How is it taken?

You swallow the capsules whole with water, twice a day, roughly 12 hours apart. Food changes how much nilotinib your body absorbs, so you take each dose on an empty stomach, with no food for two hours before and one hour after. Avoid grapefruit and grapefruit juice. Your doctor decides the dose, and your pharmacist explains the timing. Never stop or change it on your own, because CML control depends on taking it every day.

Common side effects

• Skin rash and itching
• Headache, tiredness and muscle or joint aches
• Nausea, constipation or loose stools
• Low platelet or white cell counts in the first few months
• Higher blood sugar or cholesterol, picked up on routine tests

Contact your doctor straight away if you faint, feel your heart racing or beating unevenly, get chest pain, notice pain or coldness in a leg, or have severe pain in the upper abdomen.

Storage

Keep the capsules in their original pack below 30°C, away from damp places such as the bathroom. Store them out of the reach of children.

How to order from MedHub

1. Send a photo of your prescription on WhatsApp.
2. Our pharmacist confirms the price and stock with you.
3. We pack the capsules with care and deliver them to your home or hospital.

CML treatment runs for years, and many sons and daughters in the UAE, UK and Saudi Arabia arrange each refill of Nilosigna 200mg for a parent back home through MedHub. We also stock the same medicine as Nitonib 200mg (nilotinib) and Nitonib 150mg, along with imatinib such as Imatigliv 400mg. See all our oncology medicines.

For healthcare professionals

• Composition: nilotinib (as hydrochloride monohydrate) 200 mg per hard capsule
• Drug class: BCR-ABL tyrosine kinase inhibitor (second generation)
• Indications: adults with newly diagnosed Philadelphia chromosome-positive CML in the chronic phase; adults with chronic or accelerated phase Ph+ CML resistant or intolerant to prior therapy including imatinib; paediatric patients aged 1 year and older with newly diagnosed chronic phase Ph+ CML, or chronic phase Ph+ CML resistant or intolerant to prior therapy
• Mechanism: binds the inactive conformation of the ABL kinase domain with high affinity, inhibiting BCR-ABL signalling, including many imatinib-resistant mutants
• Label dose: newly diagnosed CML: 300 mg twice daily; resistant or intolerant CML: 400 mg twice daily; paediatric: 230 mg/m² twice daily (maximum single dose 400 mg). Take about 12 hours apart, fasting 2 hours before and 1 hour after each dose
• Monitoring / key precautions: QT prolongation and sudden deaths reported; obtain ECG at baseline, 7 days after starting and after dose changes; correct hypokalaemia and hypomagnesaemia before use; avoid strong CYP3A4 inhibitors and QT-prolonging drugs; full blood count every 2 weeks for 2 months, then monthly; monitor lipase, liver function, lipids and glucose; watch for cardiovascular events including peripheral arterial occlusive disease; can cause fetal harm
• Storage: below 30°C; protect from moisture
• Marketed in Pakistan by: Oncogen Pharma
• Pack: 120 capsules

Frequently asked questions

What is Nilosigna 200mg used for?

Nilosigna 200mg treats Philadelphia chromosome-positive chronic myeloid leukaemia (CML). Doctors use it for newly diagnosed patients and for those whose CML did not respond to imatinib or who could not tolerate it.

What is the Nilosigna 200mg price in Pakistan?

Nilosigna 200mg costs Rs 48,000 to Rs 252,550 per pack of 120 capsules. Prices can change with supply, so message us on WhatsApp for today’s price before you order.

Can I get Nilosigna 200mg in Lahore, Karachi or Peshawar?

Yes. We deliver it across Pakistan, including Islamabad, Rawalpindi, Lahore, Karachi, Peshawar, Multan and Faisalabad.

Is a prescription needed for Nilosigna 200mg?

Yes. Nilotinib is a prescription-only cancer medicine. Share a clear photo of your haematologist’s prescription on WhatsApp, and our pharmacist reviews it before we confirm the order.

How do I take Nilosigna 200mg?

You swallow the capsules whole, twice a day, on an empty stomach. Leave two hours without food before each dose and one hour after it. Your doctor sets the dose.

Why must Nilosigna 200mg be taken without food?

Food, especially a fatty meal, raises the amount of nilotinib in the blood. Higher levels increase the risk of heart rhythm problems, so a fixed fasting window keeps each dose safe and predictable.

Which tests will I need while on Nilosigna 200mg?

Expect regular blood counts, a heart tracing (ECG) and checks on your liver, pancreas, sugar and cholesterol. Your haematologist also measures BCR-ABL levels every few months to see how well the CML is responding.

Can I send Nilosigna 200mg to my parents in Pakistan from abroad?

Yes. Families in the UAE, UK and Saudi Arabia often order through MedHub. Send the prescription on WhatsApp, and our team arranges payment and delivery to your parents’ home or hospital.

Last updated: 3 October 2026

This information is for general awareness only and is not medical advice. Always consult your doctor before starting, stopping or changing any medicine.