Nitonib® 200mg Capsules (Nilotinib) – Targeted Therapy (Rx)

Quick answer: Nitonib 200mg (nilotinib) is a capsule for Philadelphia chromosome-positive chronic myeloid leukaemia (CML), often used when imatinib has not worked or could not be continued. It is taken by mouth at home. MedHub supplies it on prescription and delivers across Pakistan.

For patients and families

What is Nitonib 200mg?

Nitonib 200mg contains 200mg of nilotinib in each capsule. Pharmasol manufactures and markets it in Pakistan. Nilotinib is a second-generation tyrosine kinase inhibitor, which means it was designed to block the BCR-ABL protein more tightly than older medicines. That makes it useful when CML cells have learned to escape imatinib.

What is it used for?

Nitonib 200mg is prescribed for Philadelphia chromosome-positive CML, including:

• CML resistant to earlier treatment: chronic or accelerated phase disease that kept growing on imatinib or another prior therapy.
• Intolerance to earlier treatment: when side effects from imatinib were too severe to carry on.
• Newly diagnosed chronic phase CML: in adults and in children aged one year and older.

Before a switch, your haematologist may order a mutation test to check that nilotinib suits your type of CML.

How is it taken?

You take these capsules twice daily, morning and evening, and swallow them whole with a glass of water. Eat nothing for two hours before each dose and for one hour after it. Skip grapefruit and grapefruit juice, and check with your pharmacist before starting any new medicine or herbal remedy. Your doctor decides the dose and adjusts it based on your blood tests and heart tracing.

Common side effects

• Rash, itching and thinning hair
• Feeling tired or having headaches
• Aching muscles, joints or bones
• Nausea, constipation or diarrhoea
• Low blood counts, especially early in treatment

Seek medical help at once if you black out, feel palpitations, get chest tightness, develop sudden weakness or numbness on one side, or notice a painful, pale or cold leg.

Storage

Keep the strips in their carton below 30°C and protect them from humidity. Keep them out of the reach of children.

How to order from MedHub

1. Send a photo of your prescription on WhatsApp.
2. Our pharmacist confirms the price and stock with you.
3. We deliver the carton to your home or treating hospital.

Many families in the UAE, UK and Saudi Arabia keep a parent’s monthly supply of Nitonib 200mg on track by ordering through us from abroad. For newly diagnosed patients on the lower dose, we stock Nitonib 150mg. Another nilotinib brand we carry is Nilosigna 200mg, and you can also see Glynib 400mg (imatinib) or our wider oncology range.

For healthcare professionals

• Composition: nilotinib (as hydrochloride monohydrate) 200 mg per hard capsule
• Drug class: second-generation BCR-ABL tyrosine kinase inhibitor
• Indications: adults with chronic or accelerated phase Philadelphia chromosome-positive CML resistant or intolerant to prior therapy including imatinib; adults and paediatric patients aged 1 year and older with newly diagnosed Ph+ CML in the chronic phase; paediatric patients with chronic phase Ph+ CML resistant or intolerant to prior therapy
• Mechanism: competitive inhibitor at the ATP-binding site of BCR-ABL, with higher potency than imatinib and activity against most kinase domain mutations other than T315I
• Label dose: resistant or intolerant chronic or accelerated phase CML: 400 mg orally twice daily; newly diagnosed chronic phase CML: 300 mg twice daily; paediatric: 230 mg/m² twice daily. Dose 12 hours apart, with no food 2 hours before and 1 hour after
• Monitoring / key precautions: boxed warning for QT prolongation and sudden deaths; baseline ECG, repeat at 7 days and after dose changes; do not use in hypokalaemia, hypomagnesaemia or long QT syndrome; avoid strong CYP3A4 inhibitors and QT-prolonging drugs; CBC every 2 weeks for 2 months then monthly; check lipase, amylase, liver tests, lipids and glucose; monitor for ischaemic heart disease, stroke and peripheral arterial occlusive disease; reduce dose in hepatic impairment; not for use in pregnancy
• Storage: below 30°C; protect from moisture
• Manufactured and marketed in Pakistan by: Pharmasol (Pvt) Ltd
• Pack: 112 capsules

Frequently asked questions

Who usually needs Nitonib 200mg?

Nitonib 200mg is mainly for people with Philadelphia chromosome-positive CML that resisted imatinib or caused side effects they could not tolerate. Some newly diagnosed patients also receive it.

What is the Nitonib 200mg price in Pakistan?

Nitonib 200mg costs Rs 121,968 per pack of 112 capsules. Prices can change with supply, so message us on WhatsApp for today’s price before you order.

Is Nitonib 200mg available in Lahore, Karachi or Peshawar?

Yes. We send it to patients in Islamabad, Rawalpindi, Lahore, Karachi, Peshawar, Multan and Faisalabad, and to other towns across Pakistan.

Does Nitonib 200mg need a prescription?

Yes. It is a prescription-only CML medicine. WhatsApp us a clear photo of the prescription from your haematologist or oncologist, and our pharmacist verifies it before dispatch.

When should I take Nitonib 200mg each day?

Take it twice a day, about 12 hours apart, on an empty stomach. Many patients choose fixed times, such as 9am and 9pm, and plan meals around them.

Is Nitonib 200mg a good option after imatinib fails?

For many patients, yes. Nilotinib works against most imatinib-resistant forms of CML, although one mutation called T315I does not respond. Your haematologist decides after reviewing your test results.

Why do I need heart tests while on Nitonib 200mg?

Nilotinib can change the heart’s electrical rhythm. Your doctor checks an ECG before you start, after the first week and from time to time, together with potassium and magnesium levels.

How can I order Nitonib 200mg for my father or mother in Pakistan?

Message the prescription to MedHub on WhatsApp from the UAE, UK, Saudi Arabia or anywhere else. We confirm the price, take payment and deliver to your parent’s address in Pakistan.

Last updated: 3 October 2026

This information is for general awareness only and is not medical advice. Always consult your doctor before starting, stopping or changing any medicine.