Nitonib® 150mg Capsules (Nilotinib) – Targeted Therapy (Rx)

Quick answer: Nitonib 150mg (nilotinib) is an oral targeted medicine for chronic myeloid leukaemia (CML) that carries the Philadelphia chromosome. The 150mg capsule is the strength most often used when CML is first diagnosed. MedHub supplies it on prescription and delivers to every city in Pakistan.

For patients and families

What is Nitonib 150mg?

Nitonib 150mg is a capsule of nilotinib, made and marketed in Pakistan by Pharmasol. Nilotinib targets BCR-ABL, the abnormal protein that drives CML. When the protein is blocked, the bone marrow stops overproducing leukaemia cells, and many patients reach a deep, lasting response while they keep taking it.

What is it used for?

Specialists use nilotinib for Philadelphia chromosome-positive CML:

• First treatment in the chronic phase: for adults and children newly diagnosed with CML. This is where the 150mg strength usually fits.
• After imatinib or other earlier therapy: for chronic or accelerated phase CML that stopped responding, or when side effects made earlier treatment too hard to continue.

A BCR-ABL blood test confirms the diagnosis and later shows how well the treatment is working.

How is it taken?

Nitonib 150mg is taken by mouth twice a day, with about 12 hours between doses. Swallow each capsule whole. Take it on an empty stomach: stop eating two hours before a dose and wait one hour afterwards before you eat again. Grapefruit and some common medicines raise nilotinib levels, so tell every doctor and pharmacist that you take it. Your doctor decides the dose.

Common side effects

• Headache and tiredness
• Itchy skin, dry skin or a rash
• Muscle pain, joint pain and back pain
• Nausea and changes in bowel habit
• Changes in blood counts, sugar, cholesterol or liver tests

Get urgent help if you feel dizzy or faint, notice a fast or irregular heartbeat, develop chest or leg pain, or have yellow skin or eyes.

Storage

Store the pack below 30°C in a dry place, with the capsules kept in the original packaging until you take them. Keep it away from children.

How to order from MedHub

1. Send a photo of your prescription on WhatsApp.
2. Our pharmacist confirms the price and stock with you.
3. We deliver the pack to your door or your hospital.

If you live in the UAE, UK or Saudi Arabia and a parent in Pakistan takes Nitonib 150mg, you can order monthly supplies through us without travelling home. When your haematologist moves you to the higher strength, we carry Nitonib 200mg, and also Nilosigna 200mg (nilotinib). Browse our full range of oncology medicines.

For healthcare professionals

• Composition: nilotinib (as hydrochloride monohydrate) 150 mg per hard capsule
• Drug class: BCR-ABL tyrosine kinase inhibitor
• Indications: adults and paediatric patients aged 1 year and older with newly diagnosed Philadelphia chromosome-positive CML in the chronic phase; adults with chronic or accelerated phase Ph+ CML resistant or intolerant to prior therapy including imatinib; paediatric patients with chronic phase Ph+ CML resistant or intolerant to prior therapy
• Mechanism: selective inhibitor of the BCR-ABL kinase that binds the ATP-binding site in its inactive conformation; active against most imatinib-resistant BCR-ABL mutations except T315I
• Label dose: newly diagnosed chronic phase CML: 300 mg (2 x 150 mg) orally twice daily; resistant or intolerant CML: 400 mg twice daily; paediatric: 230 mg/m² twice daily, rounded to the nearest 50 mg. Give 12 hours apart without food (no food 2 hours before and 1 hour after)
• Monitoring / key precautions: risk of QT prolongation and sudden death; ECG at baseline, at 7 days and periodically; correct potassium and magnesium; avoid strong CYP3A4 inhibitors and inducers and other QT-prolonging drugs; blood counts every 2 weeks for the first 2 months, then monthly; monitor serum lipase, hepatic function, lipid profile and glucose; assess cardiovascular risk; embryo-fetal toxicity
• Storage: below 30°C; protect from moisture
• Manufactured and marketed in Pakistan by: Pharmasol (Pvt) Ltd
• Pack: 120 capsules

Frequently asked questions

What is Nitonib 150mg prescribed for?

Nitonib 150mg treats Philadelphia chromosome-positive chronic myeloid leukaemia. Haematologists mostly choose the 150mg strength for adults whose CML has just been diagnosed and is in the chronic phase.

What is the Nitonib 150mg price in Pakistan?

Nitonib 150mg costs Rs 98,000 per pack of 120 capsules. Prices can change with supply, so message us on WhatsApp for today’s price before you order.

Do you deliver Nitonib 150mg to Lahore, Karachi or Peshawar?

Yes. MedHub delivers to all major cities, including Islamabad, Rawalpindi, Lahore, Karachi, Peshawar, Multan and Faisalabad, and to smaller towns too.

Can I buy Nitonib 150mg without a prescription?

No. You need a valid prescription from your doctor. Send us a photo of it on WhatsApp, and our pharmacist checks the details before your order goes out.

How should Nitonib 150mg be taken?

Take the capsules by mouth twice a day, about 12 hours apart, on an empty stomach. Your doctor sets the dose and tells you how long to continue.

Why is Nitonib 150mg used for new patients and 200mg for others?

The label sets a lower dose for newly diagnosed CML and a higher dose when CML has resisted earlier treatment. The 150mg capsule matches the first dose; the 200mg capsule matches the second.

Can I open Nitonib 150mg capsules if I struggle to swallow?

Ask your doctor or pharmacist first. The label allows the contents to be mixed with a teaspoon of applesauce and taken straight away, but you should only do this on their advice.

Can family abroad order Nitonib 150mg for a parent in Pakistan?

Yes. Children living in the UAE, UK and Saudi Arabia regularly order through MedHub. Share the prescription on WhatsApp, pay online, and we deliver to your parent’s home.

Last updated: 3 October 2026

This information is for general awareness only and is not medical advice. Always consult your doctor before starting, stopping or changing any medicine.