Imatigliv® 400mg Tablets (Imatinib) – Targeted Therapy (Rx)

Quick answer: Imatigliv 400mg (imatinib) is a targeted cancer tablet for chronic myeloid leukaemia (CML), gastrointestinal stromal tumours (GIST) and a few rarer blood and skin cancers. You take it by mouth at home, with food. MedHub supplies it on prescription and delivers it to every city in Pakistan.

For patients and families

What is Imatigliv 400mg?

Imatigliv 400mg is a film-coated tablet of imatinib, marketed in Pakistan by Oncogen Pharma. Imatinib is a tyrosine kinase inhibitor. Instead of attacking every fast-growing cell the way older chemotherapy does, it switches off the faulty signal that drives certain cancer cells to multiply. For many people with CML, it turns a serious blood cancer into a long-term condition that they manage with daily tablets and regular blood tests.

What is it used for?

Oncologists and haematologists prescribe imatinib for:

• Chronic myeloid leukaemia (CML): Philadelphia chromosome-positive CML in adults and children, at any phase.
• Gastrointestinal stromal tumours (GIST): KIT (CD117)-positive tumours that cannot be removed or have spread, and after surgery to lower the chance of the tumour coming back.
• Philadelphia-positive acute lymphoblastic leukaemia (ALL): usually alongside chemotherapy.
• Rarer conditions: some myelodysplastic or myeloproliferative diseases, hypereosinophilic syndrome, systemic mastocytosis and a skin tumour called dermatofibrosarcoma protuberans.

The 400mg strength suits adults on the standard daily dose for CML in chronic phase or for GIST. For smaller or adjusted doses, your doctor may prescribe Imatigliv 100mg tablets instead.

How is it taken?

You swallow imatinib with a meal and a large glass of water, which helps to settle the stomach. Take it at about the same time each day, and do not stop because you feel well. Your doctor decides the dose and adjusts it based on your blood counts and how you respond. Avoid grapefruit and grapefruit juice, and tell your doctor about every other medicine or herbal remedy you use, because several of them change imatinib levels in the blood.

Common side effects

• Puffiness around the eyes, or swollen ankles and hands
• Nausea, vomiting and loose stools
• Muscle cramps and aching bones or joints
• Skin rash and tiredness
• Low blood counts in the first months, found on routine tests

Contact your doctor straight away if you gain weight quickly, become short of breath, notice yellow skin or eyes, or develop a fever, unusual bleeding or black stools.

Storage

Keep the tablets in their original pack below 30°C and away from moisture, so a humid bathroom is not a good place for them. Store them out of sight and reach of children. Carers who handle the tablets should avoid crushing them.

How to order from MedHub

1. Send a photo of your prescription on WhatsApp.
2. Our pharmacist confirms the price and stock with you.
3. We pack your tablets carefully and deliver them to your home or hospital.

CML treatment runs for years, and many families in the UAE, UK and Saudi Arabia arrange monthly refills of Imatigliv 400mg for parents in Pakistan through us. We also stock Glynib 400mg (imatinib), made in Pakistan, and Nilosigna 200mg (nilotinib) for patients who need a different CML medicine. Browse all our oncology medicines.

For healthcare professionals

• Composition: imatinib (as mesylate) 400 mg per film-coated tablet
• Drug class: BCR-ABL tyrosine kinase inhibitor
• Indications: Ph+ CML in chronic, accelerated or blast phase (adults and children); Ph+ ALL; MDS/MPD with PDGFR gene rearrangements; aggressive systemic mastocytosis; hypereosinophilic syndrome and/or chronic eosinophilic leukaemia; dermatofibrosarcoma protuberans; Kit (CD117)-positive unresectable or metastatic GIST and adjuvant treatment after resection of GIST
• Mechanism: competitive inhibition of the ATP-binding site of BCR-ABL, KIT and PDGFR tyrosine kinases, blocking proliferation and inducing apoptosis in cells that depend on these kinases
• Label dose: CML chronic phase 400 mg once daily; accelerated phase or blast crisis 600 mg once daily; GIST 400 mg once daily (adjuvant for 3 years); Ph+ ALL 600 mg daily; DFSP 800 mg daily (400 mg twice daily); take with a meal and a large glass of water
• Monitoring / key precautions: full blood count weekly for the first month, every 2 weeks in the second month, then periodically; liver function at baseline and monthly; weigh regularly for fluid retention; caution in cardiac disease; screen for hepatitis B before starting; avoid strong CYP3A4 inducers and inhibitors; monitor growth in children; effective contraception required
• Storage: below 30°C, protect from moisture
• Marketed in Pakistan by: Oncogen Pharma
• Pack: 30 tablets

Frequently asked questions

What is Imatigliv 400mg used for?

Imatigliv 400mg mainly treats chronic myeloid leukaemia (CML) and gastrointestinal stromal tumours (GIST). Doctors also use imatinib for Philadelphia-positive ALL and a handful of rare blood and skin conditions.

What is the Imatigliv 400mg price in Pakistan?

Imatigliv 400mg costs Rs 21,000 to Rs 69,000 per pack of 30 tablets. Prices can change with supply, so message us on WhatsApp for today’s price before you order.

Can I get Imatigliv 400mg in Lahore, Karachi or Peshawar?

Yes. We deliver across Pakistan, including Islamabad, Rawalpindi, Lahore, Karachi, Peshawar, Multan and Faisalabad, usually within a few days of confirming your order.

Do I need a prescription to buy Imatigliv 400mg?

Yes. Imatinib is a prescription-only cancer medicine. Share a clear photo of your oncologist’s or haematologist’s prescription on WhatsApp, and our pharmacist checks it before we dispatch.

Should I take Imatigliv 400mg with food?

Yes. Take each dose with a meal and a full glass of water to reduce nausea and stomach upset. Your doctor or pharmacist explains the best time of day for you.

Why would my doctor choose Imatigliv 400mg over the 100mg tablets?

The 400mg tablet covers the usual adult daily dose in one tablet, which is simpler for long-term treatment. The 100mg tablets help when your doctor lowers the dose because of side effects, or prescribes a dose for a child.

How should Imatigliv 400mg be stored?

Store the tablets below 30°C in their original pack, away from damp and direct sunlight, and keep them out of reach of children.

Can I order Imatigliv 400mg for my parents in Pakistan from abroad?

Yes. Send the prescription on WhatsApp from the UAE, UK, Saudi Arabia or anywhere else, and our team arranges payment and regular delivery to your parents’ home.

Last updated: 3 October 2026

This information is for general awareness only and is not medical advice. Always consult your doctor before starting, stopping or changing any medicine.