Lepta® 250mg Tablets (Lapatinib) – Targeted Therapy (Rx)

Quick answer: Lepta 250mg (lapatinib) is a targeted tablet for HER2-positive breast cancer that has spread or come back. Doctors prescribe it together with capecitabine or an aromatase inhibitor. MedHub supplies it on prescription and delivers across Pakistan, so treatment can continue at home.

For patients and families

What is Lepta 250mg?

Lepta 250mg is an oral tablet containing 250 mg of lapatinib, made in Pakistan by Pharmasol. Some breast cancers carry too much of a protein called HER2, which pushes the cells to grow fast. Lapatinib blocks the signals from HER2 inside the cell, so the cancer grows more slowly.

What is it used for?

This tablet treats advanced or metastatic breast cancer that tests positive for HER2. Your oncologist may combine it with:

• Capecitabine: for women who have already had other treatment, including trastuzumab. We also supply Capcita 500mg (capecitabine).
• An aromatase inhibitor such as letrozole: for postmenopausal women whose cancer is both HER2-positive and hormone receptor-positive.

A pathology test must confirm HER2 status before treatment begins.

How is it taken?

You take the tablet by mouth once a day. The timing around meals matters, because food changes how much medicine your body absorbs. Your doctor or pharmacist tells you exactly when to take it and how many tablets make up your dose. Swallow the tablets whole and do not chew them. Avoid grapefruit and grapefruit juice.

Common side effects

• Diarrhoea, which can be heavy
• Rash or dry skin
• Nausea and tiredness
• Sore, red palms and soles when combined with capecitabine
• Mouth sores

Contact your care team straight away if diarrhoea does not settle, or if you notice breathlessness, swollen ankles, a racing or uneven heartbeat, yellow skin or eyes, or a dry cough that persists.

Storage

Keep the tablets below 30°C in the original pack and protect them from moisture. Store them out of the reach of children.

How to order from MedHub

1. Send a photo of your prescription on WhatsApp.
2. Our pharmacist confirms the price and stock with you.
3. We deliver the pack to your home or hospital.

If you live in the UAE, UK or Saudi Arabia, you can arrange this treatment for a mother or sister in Pakistan by sending the prescription on WhatsApp. For antibody-based HER2 treatment, see Kadcyla 100mg (trastuzumab emtansine), and browse the full oncology range.

For healthcare professionals

• Composition: lapatinib (as ditosylate) 250 mg per film-coated tablet
• Drug class: dual EGFR (HER1) and HER2 tyrosine kinase inhibitor
• Indications: HER2-overexpressing advanced or metastatic breast cancer, with capecitabine after prior therapy including an anthracycline, a taxane and trastuzumab; with letrozole in postmenopausal women with hormone receptor-positive disease
• Mechanism: reversibly inhibits the intracellular tyrosine kinase domains of EGFR and HER2, which blocks downstream proliferation pathways
• Label dose: with capecitabine, 1,250 mg (5 tablets) once daily continuously, with capecitabine 2,000 mg/m²/day on days 1–14 of a 21-day cycle; with letrozole, 1,500 mg once daily; take at least 1 hour before or 1 hour after food, as a single daily dose
• Monitoring / key precautions: assess LVEF before treatment and periodically; consider QT prolongation and correct electrolytes; monitor liver function before and during therapy; manage diarrhoea early; watch for interstitial lung disease; avoid strong CYP3A4 inhibitors and inducers, and grapefruit; reduce the dose in severe hepatic impairment; avoid in pregnancy
• Storage: below 30°C, protected from moisture
• Manufactured and marketed in Pakistan by: Pharmasol (Pvt) Ltd
• Pack: 70 tablets

Frequently asked questions

What is Lepta 250mg used for?

It treats HER2-positive breast cancer that has spread or returned. Doctors use it with capecitabine or with letrozole.

What is the Lepta 250mg price in Pakistan?

Lepta 250mg costs Rs 85,313 per pack of 70 tablets. Prices can change with supply, so message us on WhatsApp for today’s price before you order.

Can I get Lepta 250mg in Lahore, Karachi or Peshawar?

Yes. MedHub delivers across Pakistan, including Islamabad, Rawalpindi, Lahore, Karachi, Peshawar, Multan and Faisalabad.

Do I need a prescription for Lepta 250mg?

Yes. It is a prescription-only cancer medicine. Send a clear photo of the prescription on WhatsApp, and our pharmacist checks it before confirming your order.

How do I take Lepta 250mg with food?

Take it exactly as your doctor directs, since food changes how well your body absorbs it. Your pharmacist can explain the timing, and you should avoid grapefruit.

How should I store Lepta 250mg?

Keep it below 30°C in its original pack, away from moisture. It does not need a fridge.

Do I need a HER2 test before Lepta 250mg?

Yes. This tablet only helps cancers that are HER2-positive. Your oncologist confirms this on a biopsy or surgical sample before prescribing it.

Can I order Lepta 250mg for my mother in Pakistan from abroad?

Yes. Many families in the UAE, UK and Saudi Arabia order through MedHub. Share the prescription on WhatsApp, and our team guides you through payment and delivery.

Last updated: 3 October 2026

This information is for general awareness only and is not medical advice. Always consult your doctor before starting, stopping or changing any medicine.