Rituxim® 500mg/50ml Injection (Rituximab) – Targeted Therapy (Rx)

Quick answer: Rituxim 500mg (rituximab) is PharmEvo’s brand of the anti-CD20 antibody used for non-Hodgkin lymphoma, chronic lymphocytic leukaemia and rheumatoid arthritis. It runs into a vein as a hospital infusion. MedHub supplies it against a valid prescription and ships it chilled to patients and hospitals throughout Pakistan.

For patients and families

What is Rituxim 500mg?

Rituxim 500mg is a single-use vial containing 500mg of rituximab in 50ml of liquid. PharmEvo markets it in Pakistan. Rituximab belongs to a group of medicines called monoclonal antibodies. Think of it as a guided signal: it sticks to CD20, a protein found on B lymphocytes, and calls in the body’s own defences to remove those cells. Lymphoma cells and the B cells that inflame joints in rheumatoid arthritis both carry this marker.

What is it used for?

• Lymphoma: B-cell non-Hodgkin lymphomas such as follicular lymphoma and diffuse large B-cell lymphoma. It is often part of a chemotherapy combination, and some patients continue it alone afterwards to keep the disease controlled.
• CLL: chronic lymphocytic leukaemia, given with chemotherapy.
• Rheumatoid arthritis: together with methotrexate in adults whose arthritis stays active despite other biological medicines.

Only your specialist can tell whether rituximab fits your situation, so bring all recent reports to your appointment.

How is it given?

Treatment takes place in a hospital ward or day-care chemotherapy unit. A nurse sets up a drip in your arm and runs the diluted medicine in slowly, increasing the speed step by step. Before each session you usually take medicines that lower the chance of a reaction. Your doctor decides the dose and how many sessions you need. Plan for a long first visit and bring something to eat and read.

Common side effects

• Shivers, high temperature or itchy rash while the drip is running
• Low blood pressure or feeling faint during the infusion
• Infections of the nose, throat, chest or bladder
• Lower white blood cell counts on blood tests
• Muscle aches and tiredness

Tell a doctor at once about swelling of the tongue or throat, chest pain, a fever that will not settle, yellow skin, blistering, or unusual confusion or clumsiness.

Storage

The vial needs refrigeration at 2–8°C and protection from light, so leave it in the carton. Freezing ruins it. MedHub ships it with ice packs and temperature control. See how we keep medicines cold during delivery.

How to order from MedHub

1. Send a photo of your prescription on WhatsApp.
2. Our pharmacist confirms the price and stock with you.
3. We deliver the vial in a cold-chain box to the address you choose.

A growing number of overseas Pakistanis in the UAE, UK and Saudi Arabia buy Rituxim 500mg for a mother or father under treatment at home. For smaller dose adjustments, ask about Rituxim 100mg/10ml. We also keep Ristova 500mg/50ml (rituximab), and you can see everything under oncology medicines.

For healthcare professionals

• Composition: rituximab 500 mg/50 ml (10 mg/ml) concentrate for solution for infusion
• Drug class: anti-CD20 monoclonal antibody (chimeric IgG1)
• Indications: CD20-positive B-cell non-Hodgkin lymphoma, including follicular lymphoma (induction with chemotherapy, maintenance, and relapsed or refractory disease) and diffuse large B-cell lymphoma with CHOP; CLL in combination with chemotherapy; severe active rheumatoid arthritis with methotrexate after inadequate response to TNF inhibitor therapy
• Mechanism: binding to CD20 triggers B-cell lysis via complement-dependent cytotoxicity and antibody-dependent cellular cytotoxicity, and promotes apoptosis
• Label dose: NHL 375 mg/m² per infusion as per regimen; CLL 375 mg/m² in the first cycle and 500 mg/m² in cycles 2–6; rheumatoid arthritis 1000 mg IV followed by a second 1000 mg infusion two weeks later
• Monitoring / key precautions: premedicate with paracetamol and an antihistamine, with a glucocorticoid as per label; first infusion at 50 mg/h, escalating in 50 mg/h steps every 30 minutes to a maximum of 400 mg/h; screen for HBV; monitor for infusion-related reactions, tumour lysis syndrome, PML, cardiac disease and severe mucocutaneous reactions; consider withholding antihypertensives 12 hours before infusion; avoid live vaccines
• Storage: 2–8°C, in the outer carton, do not freeze
• Marketed in Pakistan by: PharmEvo (Pvt) Ltd
• Pack: 1 vial (50 ml)

Frequently asked questions

Which diseases is Rituxim 500mg prescribed for?

Doctors prescribe it for B-cell non-Hodgkin lymphoma, chronic lymphocytic leukaemia and rheumatoid arthritis. In the cancers it is usually combined with chemotherapy.

What is the Rituxim 500mg price in Pakistan?

Rituxim 500mg costs Rs 41,500 to Rs 75,000 per vial. Prices can change with supply, so message us on WhatsApp for today’s price before you order.

Do you deliver Rituxim 500mg to Lahore, Karachi or Peshawar?

Yes, along with Islamabad, Rawalpindi, Lahore, Karachi, Peshawar, Multan and Faisalabad. Each order travels chilled in a cold-chain box.

Can I buy Rituxim 500mg without a prescription?

No. This is a prescription-only specialist medicine. Share a photo of your doctor’s prescription on WhatsApp and our pharmacist confirms it before dispatch.

Where is Rituxim 500mg given?

Only in a hospital or day-care unit, as a slow drip into a vein. Staff monitor you throughout, because reactions can happen, especially the first time.

How do I keep Rituxim 500mg cold?

Store the unopened vial in a fridge at 2–8°C and never in the freezer. For travel to hospital, a cool bag with ice packs works well.

Can I have vaccines while on Rituxim 500mg?

Avoid live vaccines during treatment and for some time afterwards. Ask your doctor before any vaccine, ideally before treatment begins, because rituximab can weaken your response.

How can relatives abroad order Rituxim 500mg for a parent?

Send the prescription and the patient’s address on WhatsApp. Our team in Pakistan confirms the price, takes payment and delivers to the home or hospital.

Last updated: 3 October 2026

This information is for general awareness only and is not medical advice. Always consult your doctor before starting, stopping or changing any medicine.